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Revue des Maladies Respiratoires

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Randomized clinical trial: Impact of Bactecal® on asthma control and inflammation - 20/03/24

Doi : 10.1016/j.rmr.2024.01.010 
C. Moermans 1, ⁎, 2 , S. Graff 1, L. Medard 1, H. Nekoee 3, A.-F. Donneau 3, M.S. Njock 1, 2, C. Kempeneers 1, 4, N. Bricmont 1, 4, R. Bonhiver 1, 4, S. Gerday 1, N. Nasir 5, C. Poulet 6, M. Henket 2, V. Paulus 2, F. Guissard 2, F. Schleich 1, 2, R. Louis 1, 2
1 Giga I3, Pneumology Research Group, Liege university, Liege, Belgium 
2 Department of pneumology-allergology, CHU of Liege, 4000 Liege, Belgium 
3 Biostatistics and research method center, university of Liege, 4000 Liege, Belgium 
4 Division of respirology, department of pediatrics, CHU of Liege, Belgium 
5 Astel Medica, 4557 Tinlot, Belgium 
6 Department of rheumatology, CHU, university of Liege, 4000 Liege, Belgium 

⁎Corresponding author.

Résumé

Introduction

Asthma disease is linked to a dysbiosis. Synbiotics are a combination of probiotics and prebiotics, which are well tolerated and safe. They have been shown to have positive effects on asthma condition in in vivo models and in some studies on asthmatic patients. However, the literature focusing on their effects on asthma condition is limited and human studies are still insufficient.

Methods

We performed a double-blind randomized placebo-controlled trial to assess the impact of a synbiotic (namely Bactecal®) on asthma control, quality of life, lung function, blood and airway inflammation on uncontrolled asthmatic patients 1–3–6 months after the synbiotic intake.

Results

Compared to placebo, the synbiotic positively impacted the lung function and reduced eosinophilic airway inflammation and sputum IL-4 level.

Conclusion

The synbiotic Bactecal® had a positive impact on patients with uncontrolled asthma. It improved the lung function while decreasing airway type-2 inflammation.

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© 2024  Publié par Elsevier Masson SAS.
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Vol 41 - N° 3

P. 185 - mars 2024 Retour au numéro
Article précédent Article précédent
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