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Non-infectious pulmonary complications of myelodysplastic syndromes and chronic myeloproliferative disorders - 08/07/11

Doi : 10.1016/j.rmr.2009.04.001 
C. Lamour a, , A. Bergeron b
a Service de pneumologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France 
b Service de pneumologie, hôpital Saint-Louis, Assistance publique–Hôpitaux de Paris, université Denis Diderot – Paris 7, Paris, France 

Corresponding author. Tel.: +33 5 49 44 44 74; fax: +33 5 49 44 38 28.

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Summary

Introduction

Non-infectious pulmonary complications of myelodysplastic syndromes and chronic myeloproliferative disorders are not rare but remain little known to respiratory physicians who may be confronted with various clinical pictures corresponding to different pathophysiological causes.

Background

The few data in the literature only relate to isolated cases or small series. The non-infectious pulmonary complications of myelodysplastic syndromes and chronic myeloproliferative disorders can be classified into several clinical entities: tumour syndrome, pulmonary fibrosis or diffuse infiltrating pneumonia, autoimmune reactions including vasculitis, Sweet syndrome, organizing pneumonia, pulmonary alveolar proteinosis, pleural effusion and pulmonary arterial hypertension. The diagnosis is provided by the histology and management of these complications depends on the underlying pathology.

Viewpoints and conclusion

Myelodysplastic syndromes and myeloproliferative disorders are entities which are becoming better characterized and understood. Better knowledge of the pathophysiological mechanisms involved in these complications should improve their diagnosis and their management, which still remains complex.

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Keywords : Myelodysplastic syndromes, Chronic myeloproliferative disorders, Lung complications


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© 2011  Publié par Elsevier Masson SAS.
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Vol 28 - N° 6

P. e18-e27 - juin 2011 Retour au numéro
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