Neurocognitive impairment is correlated with oxidative stress in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome - 04/11/16

Doi : 10.1016/j.rmed.2016.09.009

Yanyu He ^a,^b, Rui Chen ^a,^b,^⁎ , Jing Wang ^a,^b, Wenying Pan ^a,^b, Yanqiu Sun ^a,^b, Fei Han ^a,^c, Qiaojun Wang ^a,^c, Chunfeng Liu ^a,^c,^d
^a Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
^b Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
^c Department of Neurology, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
^d Laboratory of Aging and Nervous Diseases, Institute of Neuroscience, Soochow University, Suzhou, China

^∗Corresponding author. Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou, 215004, China.Department of Respiratory MedicineThe Second Affiliated Hospital of Soochow UniversityNo. 1055, Sanxiang RoadSuzhou215004China

Abstract

Background and objectives

Patients with obstructive sleep apnea hypopnea syndrome (OSAHS) are associated with increased risk of neurocognitive impairment, which are largely recognized as mild cognitive impairment (MCI), and oxidative stress is postulated as one of the underlying mechanisms. This study aimed to investigate the relationship between MCI and oxidative stress biomarkers in OSAHS.

Methods

A total of 119 middle-aged patients with moderate-to-severe OSAHS were included. Based on the baseline Montreal Cognitive Assessment (MoCA, validated Chinese version), 86 and 33 patients presented with normal cognitive function (NC, MoCA ≥26) and mild cognitive impairment (MCI, MoCA <26), respectively. Overnight PSG, MoCA and serum levels of ischemia-modified albumin (IMA), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were collected and analyzed.

Results

Compared to NC group, patients with MCI were characterized with significantly greater waist-to-height ratio, AHI, ODI and time ratio of SpO₂<90%, and lower average SpO₂ and time ratio of rapid eye movement (REM). All three oxidative stress biomarkers were markedly elevated in MCI group. Binary logistic regression analysis demonstrated that MCI is significantly correlated with serum levels of IMA, REM ratio and the age of patients.

Conclusions

The neurocognitive impairment in moderate-to-severe OSAHS patients is associated with significantly elevated oxidative stress. IMA might be a new useful biomarker correlated with mild cognitive impairment of the patients.

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Highlights

•	Cognitive impairment in OSAHS patients is associated with elevated oxidative stress.
•	Cognitive impairment in the patients is largely recognized as MCI.
•	IMA might be a new useful biomarker correlated with MCI of the patients.

Le texte complet de cet article est disponible en PDF.

Keywords : Obstructive sleep apnea hypopnea syndrome, Cognitive impairment, Oxidative stress, Ischemia-modified albumin, Polysomnography

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Vol 120

P. 25-30 - novembre 2016 Retour au numéro

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