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Respiratory Medicine

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Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study - 04/11/16

Doi : 10.1016/j.rmed.2016.10.003 
Patompong Ungprasert a, ⁎ , Cynthia S. Crowson a, b, Eric L. Matteson a, c
a Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA 
b Division of Biomedical Informatics, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA 
c Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA 

∗Corresponding author. Division of Rheumatology, Mayo Clinic, 200 First avenue SW, Rochester, MN 55905, USA.Division of RheumatologyMayo Clinic200 First avenue SWRochesterMN55905USA

Abstract

Background

Smoking and obesity might alter the risk of sarcoidosis. However, the data remained inconclusive.

Methods

A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified based on individual medical record review. For each sarcoidosis subject, one sex and aged-matched control without sarcoidosis was randomly selected from the same underlying population. Medical records of cases and controls were reviewed for smoking status at index date and body mass index (BMI) within 1 year before to 3 months after index date.

Results

345 incident cases of sarcoidosis and 345 controls were identified. The odds ratio of sarcoidosis comparing current smokers with never smokers adjusted for age and sex was 0.34 (95% confidence interval (CI), 0.23–0.50). The odds ratio of sarcoidosis comparing current smokers with never smokers and former smokers adjusted for age and sex was 0.38 (95% CI, 0.26–0.56).

The odds ratio of sarcoidosis comparing overweight subjects (BMI ≥ 25 kg/m2 but < 30 kg/m2) with subjects with normal/low BMI was 1.12 (95% CI, 0.72–1.75). The odds ratio of sarcoidosis comparing obese subjects (BMI ≥ 30 kg/m2) with subjects with normal/low BMI was 2.54 (95% CI, 1.58–4.06). The odds ratio of sarcoidosis comparing obese subjects with non-obese subjects was 2.38 (95% CI, 1.60–3.56).

Conclusion

In this population, current smokers have a lower risk of developing sarcoidosis while subjects with obesity have a higher risk of developing sarcoidosis.

Le texte complet de cet article est disponible en PDF.

Highlights

•
Current smokers have a lower risk of sarcoidosis.
•
The odds of sarcoidosis was not different between former smokers and never smokers.
•
Obesity is associated with a higher risk of sarcoidosis.

Le texte complet de cet article est disponible en PDF.

Keywords : Sarcoidosis, Clinical epidemiology, Tobacco, Interstitial lung disease, Obesity, Body mass index


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© 2016  Elsevier Ltd. Tous droits réservés.
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Vol 120

P. 87-90 - novembre 2016 Retour au numéro
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