The variability of respiratory symptoms and associated factors in COPD - 26/07/17
, José Luis Izquierdo c, Cristina Esquinas a, Maite Pérez d, Myriam Calle e, José Luis López-Campos b, f, José Miguel Rodríguez González-Moro g, Ciro Casanova h, Cristóbal Esteban i, Pilar de Lucas jAbstract |
Few studies have investigated the variability of COPD-related symptoms or factors related to symptom variability.
This observational, prospective, multicentre study was conducted to describe the number and intensity of morning and night-time respiratory symptoms and their variability over one week using the Night-time and Early Morning Symptoms of COPD Instruments (NiSCI and EMSCI) to evaluate stable COPD patients. Logistic regression analyses were performed to investigate factors associated with symptom variability.
A total of 2669 patients were evaluated (mean age, 67.7 years; 80.9% men; mean FEV1 50.6%). Of these, 48% reported night-time symptoms and 71% reported morning symptoms. Of the 2293 patients who completed the NiSCI and EMSCI, 90% showed variability in either symptom number (89.6%) or symptom intensity (15.8%). More severe dyspnoea, more exacerbations during the previous year and the exacerbator or mixed COPD-asthma phenotypes were associated with variability in symptom number or intensity. Anxiety was significantly associated with variability in symptom number and intensity.
Most COPD patients showed symptom variability over a weeklong period, especially in terms of symptom number. Several COPD-related factors, mainly factors related to more severe disease and more frequent exacerbations, were associated with increased symptom variability.
El texto completo de este artículo está disponible en PDF.Highlights |
• | 48% of patients reported night-time symptoms and 71% reported morning symptoms. |
• | There is a high variability in number and intensity of symptoms over a week. |
• | Dyspnea, exacerbations and asthma-COPD are associated with variability of symptoms. |
Keywords : COPD, Symptoms, Variability, Quality of life, Sleep
Esquema
Vol 129
P. 165-172 - août 2017 Regresar al número
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