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Respiratory Medicine

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Characteristics of asthmatics with detectable IL-32? in induced sputum - 26/07/17

Doi : 10.1016/j.rmed.2017.06.005 
Jae-Woo Kwon a, 1, Hun Soo Chang b, 1, Jeong-Seok Heo b, Da-Jeong Bae b, Jong-Uk Lee b, Chang An Jung b, Ji-Hye Son b, Jong Sook Park c, Soo hyun Kim d, Kyung-Up Min e, Choon-Sik Park c, ⁎
a Division of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, South Korea 
b Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, South Korea 
c Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea 
d Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, South Korea 
e Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea 

∗Corresponding author. Division of Allergy and Respiratory Medicine, Department ofInternal Medicine, Soonchunhyang University Bucheon Hospital, 1174, Jung-Dong, Wonmi-Ku, Bucheon, Kyeonggi-Do 420-020, South Korea.Division of Allergy and Respiratory MedicineDepartment ofInternal MedicineSoonchunhyang University Bucheon Hospital1174, Jung-DongWonmi-KuBucheonKyeonggi-Do420-020South Korea

Abstract

Background

Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear.

Objective

This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma.

Methods

IL-32γ levels in the supernatant of induced sputum obtained from 89 patients with stable asthma were measured using a sandwich enzyme-linked immunosorbent assay (ELISA). The relationships between sputum IL-32γ levels and baseline forced expiratory volume in 1 s (FEV1% pred.), inflammatory cell profiles in sputum, and annual frequency of asthma exacerbation were determined.

Results

IL-32γ was detected in the sputum of 25 of 89 (28.1%) asthma patients, and the levels of sputum were negatively correlated with FEV1% pred. (ρ = −0.312, p = 0.003). The annual exacerbation rate was significantly higher in this group than in the IL-32-negative group (n = 64) (p = 0.03). Sputum IL-32γ levels correlated well with the annual exacerbation rate (ρ = 0.261, p = 0.014), but there were no differences in the inflammatory cell profiles in the induced sputum of IL-32-positive and IL-32-negative patients.

Conclusion

The level of IL-32γ in induced sputum may be associated with asthma severity and related with higher risk of asthma exacerbation.

El texto completo de este artículo está disponible en PDF.

Highlights

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IL-32γ was measured in sputum from stable asthmatics to evaluate the association between IL-32 and severity of asthma.
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IL-32γ levels were correlated negatively with FEV1 and positively with annual exacerbation rates in asthma patients.
•
Annual exacerbation rates were higher in IL-32γ detectable (+) asthmatics than in non-detectable (−) asthmatics.
•
IL-32γ levels in sputum may be associated with asthma severity and related with higher risk of asthma exacerbation.

El texto completo de este artículo está disponible en PDF.

Keywords : IL-32 γ, Asthma, Sputum, Severity, Exacerbation


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© 2017  Elsevier Ltd. Reservados todos los derechos.
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Vol 129

P. 85-90 - août 2017 Regresar al número
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